Indication  
Prolia® is a prescription medicine used to treat osteoporosis in women after menopause who:

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Help Paying for Prolia®

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Amgen believes that no one should go without the medicines they need. Therefore, Amgen provides its medicines for free or at a discount to people who do not have prescription drug or health insurance coverage and who could not otherwise afford the medicines made by Amgen.

For more information about the programs below and eligibility requirements, call ProliaPlus® at 877‑PROLIA1 (877‑776‑5421).

Prolia® Co-Pay Program for commercially-insured patients

The Prolia® Co-Pay Program helps eligible* commercially-insured patients

  • Pay $25 or less for 1 shot of Prolia® (denosumab)
  • Reduce out-of-pocket costs under the medical or pharmacy benefit
  • Apply savings to deductible, co-insurance, and/or co-pay for Prolia®
  • No income eligibility requirement

This program does not provide support for any physician-related services associated with administration of Prolia®.

*See eligibility and limits.

Eligibility Criteria: Open to patients with a Prolia® prescription and commercial insurance for Prolia®. Patients may not seek reimbursement for value received from the Prolia® Co-pay Program from any third-party payers, including a flexible spending account or healthcare savings account. This program is not open to uninsured patients or patients receiving prescription reimbursement under any federal, state, or government-funded healthcare program, such as Medicare, Medicare Advantage, Medicare Part D, Medicaid, Medigap, Veterans Affairs (VA), the Department of Defense (DoD), or TRICARE, or where prohibited by law. If at any time patients begin receiving prescription drug coverage under any such federal, state, or government-funded healthcare program, patients will no longer be able to use this card and you must call the Prolia® Co-pay Program at 1-877-PROLIA1 (1-877-776-5421) (8:00 AM - 8:00 PM EST, Monday-Friday) to stop participation. Restrictions may apply. Offer subject to change or discontinuation without notice. This is not health insurance.

Program Details: The Prolia® Co-pay Program is a coupon program that provides financial support for eligible commercially insured patients. For eligible patients, program covers the amount of OOP cost for Prolia® that exceeds $25, up to a maximum benefit of $1,000 per patient, per 12-month enrollment period. Patient is responsible for costs above this amount. The program does not provide support for supplies, procedures, or any physician-related services associated with Prolia®.

Payment assistance for Medicare, uninsured, and low-income patients

ProliaPlus® can refer eligible Medicare patients to Independent Co-pay Foundations, which may be able to provide financial assistance. Contact ProliaPlus® at 877-PROLIA1 (877-776-5421)

Important Safety Information Close

Do not take Prolia® (denosumab) if you: have low blood calcium; or are pregnant or plan to become pregnant, as Prolia® may harm your unborn baby; or are allergic to denosumab or any ingredients in Prolia®.

What is the most important information I should know about Prolia®?

If you receive Prolia®, you should not receive XGEVA®. Prolia® contains the same medicine as XGEVA® (denosumab).

Prolia® can cause serious side effects:

Serious allergic reactions have happened in people who take Prolia®. Call your doctor or go to your nearest emergency room right away if you have any symptoms of a serious allergic reaction, including low blood pressure (hypotension); trouble breathing; throat tightness; swelling of your face, lips, or tongue; rash; itching; or hives.

Low blood calcium (hypocalcemia). Prolia® may lower the calcium levels in your blood. If you have low blood calcium, it may get worse during treatment. Your low blood calcium must be treated before you receive Prolia®.

Take calcium and vitamin D as your doctor tells you to help prevent low blood calcium.

Severe jaw bone problems (osteonecrosis) may occur. Your doctor should examine your mouth before you start Prolia® and may tell you to see your dentist. It is important for you to practice good mouth care during treatment with Prolia®.

Unusual thigh bone fractures. Some people have developed unusual fractures in their thigh bone. Symptoms of a fracture include new or unusual pain in your hip, groin, or thigh.

Serious infections in your skin, lower stomach area (abdomen), bladder, or ear may happen. Inflammation of the inner lining of the heart (endocarditis) due to an infection may also happen more often in people who take Prolia®. You may need to go to the hospital for treatment.

Prolia® is a medicine that may affect the ability of your body to fight infections. People who have weakened immune systems or take medicines that affect the immune system may have an increased risk for developing serious infections.

Skin problems such as inflammation of your skin (dermatitis), rash, and eczema have been reported.

Bone, joint, or muscle pain. Some people who take Prolia® develop severe bone, joint, or muscle pain.

Before taking Prolia®, tell your doctor if you:

  • Take the medicine XGEVA® (denosumab)
  • Have low blood calcium
  • Cannot take daily calcium and vitamin D
  • Had parathyroid or thyroid surgery (glands located in your neck)
  • Have been told you have trouble absorbing minerals in your stomach or intestines (malabsorption syndrome)
  • Have kidney problems or are on kidney dialysis
  • Plan to have dental surgery or teeth removed
  • Are pregnant or plan to become pregnant
  • Are breast-feeding or plan to breast-feed

What are the possible side effects of Prolia®?

It is not known if the use of Prolia® over a long period of time may cause slow healing of broken bones. The most common side effects of Prolia® are back pain, pain in your arms and legs, high cholesterol, muscle pain, and bladder infection.

These are not all the possible side effects of Prolia®. For more information, ask your doctor or pharmacist. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Indication Prolia® is a prescription medicine used to treat osteoporosis in women after menopause who:

  • are at high risk for fracture, meaning women who have had a fracture related to osteoporosis, or who have multiple risk factors for fracture
  • cannot use another osteoporosis medicine or other osteoporosis medicines did not work well
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Important Safety Information

 Do not take Prolia® (denosumab) if you: have low blood calcium; or are pregnant or plan to become pregnant, as Prolia® may harm your unborn baby; or are allergic to denosumab or any ingredients in Prolia®.

What is the most important information I should know about Prolia®?

If you receive Prolia®, you should not receive XGEVA®. Prolia® contains the same medicine as XGEVA® (denosumab).

Prolia® can cause serious side effects: