See how Prolia® works in people with osteoporosis by moving the below bar from side to side
Without
treatment
An excess of bone-removing cells in your body makes you lose bone faster than your body can rebuild it, putting you at risk for fracture.
With
Prolia®
Prolia® is an injection that works with your body to help stop the development of bone-removing cells.
stronger with 1 shot
every 6 months
You should take calcium and vitamin D as your doctor tells you to while you receive Prolia®. After your treatment with Prolia® is stopped, or if you skip or delay taking a dose, your risk for breaking bones, including bones in your spine, is increased. Do not stop, skip or delay taking Prolia® without first talking with your doctor.
Prolia® injections administered by a healthcare professional
Once every 6 months
Oral bisphosphonate tablets
Once daily
Once weekly
Self-administered injections
Once daily
Intravenous infusion
Once yearly
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Osteoporosis treatment |
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Taking corticosteroids, like prednisone, for over 3 months can reduce bone mineral density (BMD) and may increase your risk of fracture
In fact, compared to those not on an osteoporosis treatment, men and women who continuously used corticosteroids for at least 3 months had up to a
FRACTURES*
FRACTURES*
*Based on a study of adults using corticosteroids >10 mg/day for more than 90 days.
People who took Prolia® saw a SIGNIFICANT INCREASE in the bone density of their spine and hip at 12 MONTHS, compared to those taking risedronate.†
†Risedronate is a common osteoporosis treatment.
See how Prolia® works in people with osteoporosis by moving the below bar from side to side
Without
treatment
For people with corticosteroid-induced osteoporosis, there is a decrease in bone-forming cells and an excess of bone-removing cells, causing bones to become weak and brittle.
With
Prolia®
Prolia® works by stopping the development of bone-removing cells in the body, before they can reach and damage the bone.
People who took Prolia® saw a SIGNIFICANT INCREASE in the bone density of their spine and hip at 12 MONTHS, compared to those taking risedronate.*
*Risedronate is a common osteoporosis treatment.
Prolia® injections administered by a healthcare professional
Once every 6 months
Oral bisphosphonate tablets
Once daily
Once weekly
Self-administered injections
Once daily
Intravenous infusion
Once yearly
|
Osteoporosis treatment |
|
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|---|---|---|---|
|
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|
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Frequency of dosing |
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You should take calcium and vitamin D as your doctor tells you to while you receive Prolia®.
In females who are able to become pregnant, your healthcare provider should do a pregnancy test before you start Prolia®. Use an effective method of birth control (contraception) during treatment with Prolia® and for at least 5 months after your last dose of Prolia®. Tell your doctor right away if you become pregnant while taking Prolia®.
After your treatment with Prolia® is stopped, or if you skip or delay taking a dose, your risk for breaking bones, including bones in your spine, is increased. Do not stop, skip or delay taking Prolia® without first talking with your doctor.
Prolia® is proven to help
Prolia® is proven to help
Prolia® is an injection given at your doctor's office once every 6 months
You should take calcium and vitamin D as your doctor tells you to while you receive Prolia®.
In females who are able to become pregnant, your healthcare provider should do a pregnancy test before you start Prolia®. Use an effective method of birth control (contraception) during treatment with Prolia® and for at least 5 months after your last dose of Prolia®. Tell your doctor right away if you become pregnant while taking Prolia®.
After your treatment with Prolia® is stopped, or if you skip or delay taking a dose, your risk for breaking bones, including bones in your spine, is increased. Do not stop, skip or delay taking Prolia® without first talking with your doctor.
Important Safety Information
- Take the medicine XGEVA® (denosumab)
- Have low blood calcium
- Cannot take daily calcium and vitamin D
- Had parathyroid or thyroid surgery (glands located in your neck)
- Have been told you have trouble absorbing minerals in your stomach or intestines (malabsorption syndrome)
- Have kidney problems or are on kidney dialysis
- Are taking medicine that can lower your blood calcium levels
- Plan to have dental surgery or teeth removed
- Are pregnant or plan to become pregnant
Females who are able to become pregnant:- Your healthcare provider should do a pregnancy test before you start treatment with Prolia®.
- You should use an effective method of birth control (contraception) during treatment with Prolia® and for at least 5 months after your last dose of Prolia®.
- Tell your doctor right away if you become pregnant while taking Prolia®.
- Are breast-feeding or plan to breast-feed
What are the possible side effects of Prolia®?
It is not known if the use of Prolia® over a long period of time may cause slow healing of broken bones. The most common side effects of Prolia® in women being treated for osteoporosis after menopause are back pain, pain in your arms and legs, high cholesterol, muscle pain, and bladder infection.
The most common side effects of Prolia® in men with osteoporosis are back pain, joint pain, and common cold (runny nose or sore throat).
The most common side effects of Prolia® in patients with corticosteroid-induced osteoporosis are back pain, high blood pressure, lung infection (bronchitis), and headache.
The most common side effects of Prolia® in patients receiving certain treatments for prostate or breast cancer are joint pain, back pain, pain in your arms and legs, and muscle pain. Additionally, in Prolia®-treated men with nonmetastatic prostate cancer receiving ADT, a greater incidence of cataracts was observed.
These are not all the possible side effects of Prolia®. Call your doctor for medical advice about side effects.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
Indications
Prolia® is a prescription medicine used to treat osteoporosis in women after menopause who are at high risk for fracture or cannot use another osteoporosis medicine or other osteoporosis medicines did not work well.
Prolia® is a prescription medicine used to increase bone mass in men with osteoporosis who are at high risk for fracture.
Prolia® is a prescription medicine used to treat osteoporosis in men and women who will be taking corticosteroid medicines (such as prednisone) for at least six months and are at high risk for fracture.
Prolia® is a prescription medicine used to treat bone loss in men who are at high risk for fracture receiving certain treatments for prostate cancer that has not spread to other parts of the body.
Prolia® is a prescription medicine used to treat bone loss in women who are at high risk for fracture receiving certain treatments for breast cancer that has not spread to other parts of the body.
Please see Prolia® full Prescribing Information and Medication Guide.