Indication  
Prolia® is a prescription medicine used to treat osteoporosis in women after menopause who:

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Reduce your fracture risk

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If your doctor tells you that you have postmenopausal osteoporosis and are at high risk for fracture, then you can come up with a treatment plan together, which may include diet, calcium and vitamin D supplements, exercise, and medication.

Here are some tips for helping reduce the risk of falls and fractures:

Assess your current condition.
Talk to your doctor about personal health conditions that may lead to falls. This may include impaired vision and hearing, chronic illnesses, and side effects of other medications.

Only Prolia® helps strengthen bones with 2 shots a year*

Fall-proof your home.
One way to do this is by making sure you have clear walking paths throughout your home. Other fall reduction measures include:

  • Checking that the handrails in stairways are sturdy and secure.
  • Installing handrails in bathrooms and using non-skid mats around the shower.
  • Keeping your home well-lit, including hallways, porches, stairs, and outside areas. Use nightlights throughout your home.
  • Making sure kitchen items are easy-to-reach and floors are never slippery.

Reduce your risk when out and about.
That means taking extra precautions like wearing shoes with rubber soles or avoiding highly polished marble or tile. You can also use shoulder bags or fanny packs so that your hands remain free.

Most importantly, stay aware of your surroundings. Look out for obstacles like curbs, inclines or steps.

Enhance your daily diet.
With postmenopausal osteoporosis and a high risk for fracture, boosting your daily calcium intake can help you strengthen your bones. Use calcium-rich recipes to help make sure you get enough calcium in your diet.

Get your exercise.
Regular weight-bearing and muscle-strengthening exercises may help increase bone density, maintain muscle mass, and improve flexibility and balance. Some great exercise options include walking, tai chi, stair climbing, swimming, and gardening.

Consider adding Prolia® to your treatment plan.
2 shots of Prolia® a year* are proven to help women with postmenopausal osteoporosis at high risk for fracture strengthen their bones. Ask your doctor if Prolia® is right for you.

*Taken with calcium and vitamin D.

Need help talking to your doctor?

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Important Safety Information Close

Do not take Prolia® (denosumab) if you: have low blood calcium; or are pregnant or plan to become pregnant, as Prolia® may harm your unborn baby; or are allergic to denosumab or any ingredients in Prolia®.

What is the most important information I should know about Prolia®?

If you receive Prolia®, you should not receive XGEVA®. Prolia® contains the same medicine as XGEVA® (denosumab).

Prolia® can cause serious side effects:

Serious allergic reactions have happened in people who take Prolia®. Call your doctor or go to your nearest emergency room right away if you have any symptoms of a serious allergic reaction, including low blood pressure (hypotension); trouble breathing; throat tightness; swelling of your face, lips, or tongue; rash; itching; or hives.

Low blood calcium (hypocalcemia). Prolia® may lower the calcium levels in your blood. If you have low blood calcium, it may get worse during treatment. Your low blood calcium must be treated before you receive Prolia®.

Take calcium and vitamin D as your doctor tells you to help prevent low blood calcium.

Severe jaw bone problems (osteonecrosis) may occur. Your doctor should examine your mouth before you start Prolia® and may tell you to see your dentist. It is important for you to practice good mouth care during treatment with Prolia®.

Unusual thigh bone fractures. Some people have developed unusual fractures in their thigh bone. Symptoms of a fracture include new or unusual pain in your hip, groin, or thigh.

Serious infections in your skin, lower stomach area (abdomen), bladder, or ear may happen. Inflammation of the inner lining of the heart (endocarditis) due to an infection may also happen more often in people who take Prolia®. You may need to go to the hospital for treatment.

Prolia® is a medicine that may affect the ability of your body to fight infections. People who have weakened immune systems or take medicines that affect the immune system may have an increased risk for developing serious infections.

Skin problems such as inflammation of your skin (dermatitis), rash, and eczema have been reported.

Bone, joint, or muscle pain. Some people who take Prolia® develop severe bone, joint, or muscle pain.

Before taking Prolia®, tell your doctor if you:

  • Take the medicine XGEVA® (denosumab)
  • Have low blood calcium
  • Cannot take daily calcium and vitamin D
  • Had parathyroid or thyroid surgery (glands located in your neck)
  • Have been told you have trouble absorbing minerals in your stomach or intestines (malabsorption syndrome)
  • Have kidney problems or are on kidney dialysis
  • Plan to have dental surgery or teeth removed
  • Are pregnant or plan to become pregnant
  • Are breast-feeding or plan to breast-feed

What are the possible side effects of Prolia®?

It is not known if the use of Prolia® over a long period of time may cause slow healing of broken bones. The most common side effects of Prolia® are back pain, pain in your arms and legs, high cholesterol, muscle pain, and bladder infection.

These are not all the possible side effects of Prolia®. For more information, ask your doctor or pharmacist. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Indication Prolia® is a prescription medicine used to treat osteoporosis in women after menopause who:

  • are at high risk for fracture, meaning women who have had a fracture related to osteoporosis, or who have multiple risk factors for fracture
  • cannot use another osteoporosis medicine or other osteoporosis medicines did not work well
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Important Safety Information

 Do not take Prolia® (denosumab) if you: have low blood calcium; or are pregnant or plan to become pregnant, as Prolia® may harm your unborn baby; or are allergic to denosumab or any ingredients in Prolia®.

What is the most important information I should know about Prolia®?

If you receive Prolia®, you should not receive XGEVA®. Prolia® contains the same medicine as XGEVA® (denosumab).

Prolia® can cause serious side effects: