Prolia® is a prescription medicine used to treat osteoporosis in women after menopause who are at high risk for fracture or cannot use another osteoporosis medicine or other osteoporosis medicines did not work well. Read More

Prolia® is a prescription medicine used to increase bone mass in men with osteoporosis who are at high risk for fracture. Read Less

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Prolia® Injection Reminder Text Message Program



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Program Overview
Mobile Terms and Conditions

Once enrolled in the Prolia® Patient Support Program, Prolia® patients can sign up for helpful injection appointment reminders. These reminders can be delivered through direct mail or via a phone call. Patients can choose to receive their phone call reminders from a live agent, automated voice message or through text message.

Enrollment and Getting Started:

At this time, enrollment for the Prolia® injection appointment reminder program can be completed online at or with one of our live agents at 855-618-4502.

Within the Prolia® Patient Support Program registration section on, specific to the text message option, patients will be asked to provide the following information:

  • Cell Phone number—This is the number where the patient would like the medication reminders to be delivered
  • Time Zone—This is important to provide so the text messages are delivered at an appropriate time of day

At the time of registration, patients can also view the Mobile Terms & Conditions, which is also included on this page.

Once a patient enrolls in the Prolia® Patient Support Program and chooses to receive injection appointment reminders via SMS/text message reminders, patients will receive a welcome text message from 63280 confirming their desire to enroll in the Prolia® injection reminder text program. The patient will need to reply ‘YES’ to confirm enrollment. Should the patient not confirm enrollment, they will not be enrolled in receiving injection appointment text reminders for Prolia®. See below for message example:

Injection appointment text reminders will be sent based on the injection appointment date provided during enrollment. For example:

Patient provides next injection date of December 1 = First injection appointment reminder text will be sent to you on November 19, 14 days before their next appointment date, and a second reminder will be sent on November 26, 7 days before their next appointment date. A post-appointment confirmation message will be sent on December 6, 5 days post their appointment date.

How Many Text Messages Will Patients Receive?

The amount of injection appointment text reminders received by the patient will vary per month based on their registration preference. On average, a patient may receive 1 message every two months during most months, and approx. 3-5 messages in the month of their appointment date (which will happen twice per year).

Opting Out:

A patient can opt out of the Prolia® injection appointment reminder program at any time by calling 1-855-618-4502.

Customer Support:

Should the patient have any questions about Prolia® or the Prolia® Patient Support Program please do not reply to any text message sent to you through the injection appointment reminder program, as responses are not monitored. Instead, please call 1-855-618-4502 and a helpful representative can help assist you.

Amgen’s Prolia® Reminders mobile Short Message Service (SMS) program runs on the short code 63280. Amgen will not charge you to use this Service; however your Wireless Service Provider may charge for sending and/or receiving messages and for air-time.

Amgen Inc. (“Amgen”) reserves the right, in its sole discretion, to change, modify, add, or remove these Mobile Terms of Use (“Mobile Terms”) at any time. Amgen may in its discretion change or suspend the Service (defined below) at any time. If you are dissatisfied with the Service or the content received through the Service, your sole remedy is to discontinue use of the Service.

By using the Service and accepting these terms, you also agree to Amgen’s standard Terms of Use, incorporated herein by reference. In the event of a conflict between the standard Terms of Use and these mobile terms, these Mobile Terms shall prevail.

Mobile Service:

  1. Amgen provides SMS injection appointment reminders as Prolia® Reminders (collectively, the ‘Service’). Please note that to process your requests for this Service, you may be charged a fee to send and receive messages based on the terms of your wireless service agreement. All charges are billed by and payable to your Wireless Service Provider. Check with your Wireless Service Provider if you have questions about your wireless service plan.
  2. Amgen will not be liable for any delays in the receipt of any SMS messages as delivery is subject to effective transmission from your Wireless Service Provider.
  3. This Service is available on the following carriers: AT&T, Verizon Wireless, Sprint, Virgin Mobile, Boost, T-Mobile, MetroPCS, U.S. Cellular, Cricket Wireless, Google Voice, nTelos, Alaska Communications Systems (ACS), ASTAC (Arctic Slope Telephone Cooperative Association), (includes Republic Wireless), Bluegrass Cellular, Boost-CDMA, Brightlink, C Spire Wireless (Cellular South), CableVision, Carolina West Wireless, CellCom, Cellular One of N.E. Arizona, Chariton Valley Cellular, Chat Mobility, Cleartalk (Flat Wireless), Copper Valley Telecom, Cordova Telephone Cooperative Inc dba Cordova Wireless, DTC Wireless, Duet Wireless, East Kentucky Network (Appalachian Wireless), ECIT/Cellular One of East Central Illinois, Enflick (TextNow), GCI Communications, Illinois Valley Cellular, Inland Cellular, IWireless, Inteliquent, Leaco Rural Telephone Cooperative, Limitless Mobile, Mid-Rivers Communications, Mobi PCS, MobileNation/SI Wireless, MTA Wireless/Matanuska Kenai, MTPCS Cellular One (Cellone Nation), Nemont US UMTS, Nex Tech Communications, Northwest Missouri Cellular, Panhandle Wireless, Pine Cellular, Pioneer Cellular, PinPoint Communications (Blaze Wireless), Plateau Wireless, Rural Independent Network Alliance (RINA), Sagebrush, SouthernLINC, SRT Communications, Thumb Cellular, TracFone, Triangle Mobile, Union Telephone, United Wireless, Viaero Wireless, and West Central Wireless. T-Mobile is not liable for delayed or undelivered messages.
  4. For additional questions, please call 1-855-618-4502.

Privacy Policy:

For Amgen privacy practices, please see our Privacy Policy.

Service Details:

Visit or call 1-855-618-4502 to subscribe to Prolia® SMS injection appointment reminders. You will receive recurring messages. Text HELP to 63280 for help, STOP to 63280 to cancel. Message and Data Rates May Apply.


Visit or call 1-855-618-4502 to enroll. Provide the required information including your mobile phone number. You will receive an opt-in request from 63280 to your mobile phone number. Follow the texting prompts to complete your subscription.

Prolia(R) (denosumab): You will get recurring text message reminders to schedule your injection appts. based on the date you provided when you signed up.


You can cancel receipt of all SMS messages from 63280 by replying to any Service message, or sending ‘STOP‘, ‘END‘, ‘QUIT‘, ‘UNSUBSCRIBE‘, or ‘CANCEL‘ to 63280.

Prolia(R) (denosumab): You'll no longer receive text msgs from this reminder program or 63280. To re-enroll visit or call 855-618-4502.


You can get HELP, by replying to any Service message, or sending ‘HELP’ to 63280. You can also call 1-855-618-4502 for more information.


Prolia(R) (denosumab): For questions on the Prolia(R) injection reminder program or to update your injection appointment date call 855-618-4502.

Important Safety Information Close

Do not take Prolia® if you: have low blood calcium; or are pregnant or plan to become pregnant, as Prolia® may harm your unborn baby; or are allergic to denosumab or any ingredients in Prolia®.

What is the most important information I should know about Prolia®?

If you receive Prolia®, you should not receive XGEVA®. Prolia® contains the same medicine as XGEVA®&bnsp;(denosumab).

Prolia® can cause serious side effects:

Serious allergic reactions have happened in people who take Prolia®. Call your doctor or go to your nearest emergency room right away if you have any symptoms of a serious allergic reaction, including low blood pressure (hypotension); trouble breathing; throat tightness; swelling of your face, lips, or tongue; rash; itching; or hives.

Low blood calcium (hypocalcemia). Prolia® may lower the calcium levels in your blood. If you have low blood calcium, it may get worse during treatment. Your low blood calcium must be treated before you receive Prolia®.

Take calcium and vitamin D as your doctor tells you to help prevent low blood calcium.

Severe jaw bone problems (osteonecrosis) may occur. Your doctor should examine your mouth before you start Prolia® and may tell you to see your dentist. It is important for you to practice good mouth care during treatment with Prolia®.

Unusual thigh bone fractures. Some people have developed unusual fractures in their thigh bone. Symptoms of a fracture include new or unusual pain in your hip, groin, or thigh.

Increased risk of broken bones, including broken bones in the spine, after stopping Prolia®. After your treatment with Prolia® is stopped, your risk for breaking bones, including bones in your spine, is increased. Your risk for having more than 1 broken bone in your spine is increased if you have already had a broken bone in your spine. Do not stop taking Prolia® without first talking with your doctor. If your Prolia® treatment is stopped, talk to your doctor about other medicine that you can take.

Serious infections in your skin, lower stomach area (abdomen), bladder, or ear may happen. Inflammation of the inner lining of the heart (endocarditis) due to an infection may also happen more often in people who take Prolia®. You may need to go to the hospital for treatment.

Prolia® is a medicine that may affect the ability of your body to fight infections. People who have weakened immune systems or take medicines that affect the immune system may have an increased risk for developing serious infections.

Skin problems such as inflammation of your skin (dermatitis), rash, and eczema have been reported.

Bone, joint, or muscle pain. Some people who take Prolia® develop severe bone, joint, or muscle pain.

Before taking Prolia®, tell your doctor about all of your medical conditions, including if you:

  • Take the medicine XGEVA® (denosumab)
  • Have low blood calcium
  • Cannot take daily calcium and vitamin D
  • Had parathyroid or thyroid surgery (glands located in your neck)
  • Have been told you have trouble absorbing minerals in your stomach or intestines (malabsorption syndrome)
  • Have kidney problems or are on kidney dialysis
  • Plan to have dental surgery or teeth removed
  • Are pregnant or plan to become pregnant

    Females who are able to become pregnant:

    • Your healthcare provider should do a pregnancy test before you start treatment with Prolia®.
    • You should use an effective method of birth control (contraception) during treatment with Prolia® and for at least 5 months after your last dose of Prolia®.
    • Tell your doctor right away if you become pregnant while taking Prolia®.
  • Are breast-feeding or plan to breast-feed

What are the possible side effects of Prolia®?

It is not known if the use of Prolia® over a long period of time may cause slow healing of broken bones. The most common side effects of Prolia® in women being treated for osteoporosis after menopause are back pain, pain in your arms and legs, high cholesterol, muscle pain, and bladder infection. The most common side effects of Prolia® in men with osteoporosis are back pain, joint pain, and common cold (runny nose or sore throat).

These are not all the possible side effects of Prolia®. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit, or call 1‑800‑FDA‑1088.

See More
Important Safety Information
Do not take Prolia® if you: have low blood calcium; or are pregnant or plan to become pregnant, as Prolia® may harm your unborn baby; or are allergic to denosumab or any ingredients in Prolia®..

What is the most important information I should know about Prolia®?

If you receive Prolia®, you should not receive XGEVA®. Prolia® contains the same medicine as XGEVA®&bnsp;(denosumab).

Prolia® can cause serious side effects: