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Hear From Blythe on Prolia®



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Blythe Danner is a Tony and Emmy Award-winning actress, regularly applauded for her roles on stage and screen. She's also a proud mother and grandmother who has been diagnosed with postmenopausal osteoporosis and a high risk for fracture. She and her doctor discussed a plan to help strengthen her bones, the risks and benefits of various treatment options, and determined that Prolia® (denosumab) is right for her.

Blythe's favorite calcium-rich recipes

Delicious ways to get the calcium you need

Hear more about Blythe's decision to take Prolia®

What keeps you busy these days?

My work mostly. I'm grateful to still be offered a variety of roles that are challenging and rewarding. They are typically mothers and grandmothers who are interesting (sometimes even romantic).

Of course my grandchildren give me great joy and I love spending time with them. To watch them grow and develop fills me with a tremendous sense of joy and pride. They are so much fun. If the theory that laughter fosters happiness is true, they are responsible for mine.

What else do you enjoy in your free time?

Working with environmental issues has been a passion of mine for 40 years. Along with many others I helped start the sidewalk pickup programs for recycling in New York City and Santa Monica, CA. I am also on the board of several companies that are working on environmental issues. My motivation for this has been my desire to leave the world a better place for my children and grandchildren.

How did you react when you heard you have postmenopausal osteoporosis?

When my doctor told me I have postmenopausal osteoporosis and that I'm at high risk for fracture, I wasn't as surprised as you might think. After all, I'm at the age where breaking a bone is on your mind. What surprised me more than the diagnosis, I guess, was how it made me feel... a bit more fragile. So, I'm going to do all I can to help strengthen my bones.

How have you worked with your doctor since diagnosis?

My doctor helped me understand my diagnosis and what it meant. We discussed a plan to help strengthen my bones, the risks and benefits of various treatment options, and together, we decided that Prolia® (denosumab) is the right treatment option for me. And now I know, it’s working. My bones are getting stronger.

I think it's important for any woman with postmenopausal osteoporosis and at high risk for fracture to work with her doctor, and look at all the ways to help make bones stronger. Calcium, vitamin D, and exercise—and treatment options can help. Your doctor can help you choose the path that is right for you.

Why did you and your doctor choose Prolia®?

When we were discussing my treatment options, I learned that Prolia® helps stop bone removing cells from getting to the bone and causing bone loss; and that Prolia® could help reduce my risk for fractures. And I really liked the idea that it's two shots a year, in my doctor's office, along with taking vitamin D and calcium supplements.

I love my life, acting, being with my children and grandchildren, and working to make this world a better place. So I’m going to do everything I can to help strengthen my bones.

Important Safety Information

Do not take Prolia® (denosumab) if you: have low blood calcium; or are pregnant or plan to become pregnant, as Prolia® may harm your unborn baby; or are allergic to denosumab or any ingredients in Prolia®.

What is the most important information I should know about Prolia®?

If you receive Prolia®, you should not receive XGEVA®. Prolia® contains the same medicine as XGEVA® (denosumab).

Prolia® can cause serious side effects:

Serious allergic reactions have happened in people who take Prolia®. Call your doctor or go to your nearest emergency room right away if you have any symptoms of a serious allergic reaction, including low blood pressure (hypotension); trouble breathing; throat tightness; swelling of your face, lips, or tongue; rash; itching; or hives.

Low blood calcium (hypocalcemia). Prolia® may lower the calcium levels in your blood. If you have low blood calcium, it may get worse during treatment. Your low blood calcium must be treated before you receive Prolia®.

Take calcium and vitamin D as your doctor tells you to help prevent low blood calcium.

Severe jaw bone problems (osteonecrosis) may occur. Your doctor should examine your mouth before you start Prolia® and may tell you to see your dentist. It is important for you to practice good mouth care during treatment with Prolia®.

Unusual thigh bone fractures. Some people have developed unusual fractures in their thigh bone. Symptoms of a fracture include new or unusual pain in your hip, groin, or thigh.

Serious infections in your skin, lower stomach area (abdomen), bladder, or ear may happen. Inflammation of the inner lining of the heart (endocarditis) due to an infection may also happen more often in people who take Prolia®. You may need to go to the hospital for treatment.

Prolia® is a medicine that may affect the ability of your body to fight infections. People who have weakened immune systems or take medicines that affect the immune system may have an increased risk for developing serious infections.

Skin problems such as inflammation of your skin (dermatitis), rash, and eczema have been reported.

Bone, joint, or muscle pain. Some people who take Prolia® develop severe bone, joint, or muscle pain.

Before taking Prolia®, tell your doctor if you:

  • Take the medicine XGEVA® (denosumab)
  • Have low blood calcium
  • Cannot take daily calcium and vitamin D
  • Had parathyroid or thyroid surgery (glands located in your neck)
  • Have been told you have trouble absorbing minerals in your stomach or intestines (malabsorption syndrome)
  • Have kidney problems or are on kidney dialysis
  • Plan to have dental surgery or teeth removed
  • Are pregnant or plan to become pregnant
  • Are breast-feeding or plan to breast-feed

What are the possible side effects of Prolia®?

It is not known if the use of Prolia® over a long period of time may cause slow healing of broken bones. The most common side effects of Prolia® are back pain, pain in your arms and legs, high cholesterol, muscle pain, and bladder infection.

These are not all the possible side effects of Prolia®. For more information, ask your doctor or pharmacist. Call your doctor for medical advice about side effects.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit, or call 1-800-FDA-1088.

Indication Prolia® is a prescription medicine used to treat osteoporosis in women after menopause who:

  • are at high risk for fracture, meaning women who have had a fracture related to osteoporosis, or who have multiple risk factors for fracture
  • cannot use another osteoporosis medicine or other osteoporosis medicines did not work well
Full Safety Information and Indication

Important Safety Information

Do not take Prolia® (denosumab) if you: have low blood calcium; or are pregnant or plan to become pregnant, as Prolia® may harm your unborn baby; or are allergic to denosumab or any ingredients in Prolia®.

What is the most important information I should know about Prolia®?

Important safety information & Indication